CONDITIONED ADRENOCORTICAL STEROID ELEVATIONS IN RAT

被引:84
作者
ADER, R [1 ]
机构
[1] UNIV ROCHESTER, SCH MED & DENT, DEPT PSYCHIAT, ROCHESTER, NY 14627 USA
来源
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY | 1976年 / 90卷 / 12期
关键词
D O I
10.1037/h0077290
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
An illness-induced taste aversion paradigm was used to condition an elevation in plasma corticosterone level. Rats were injected with cyclophosphamide 30 min after consuming a novel saccharin drinking solution. Plasma corticosterone levels were measured before conditioning to determine unconditioned steroid levels and 3 and 6 days after training when conditioned and nonconditioned animals were provided with the saccharin solution or plain water, or were left deprived. The pairing of saccharin and cyclophosphamide was effective in inducing a passive avoidance response. There were no differences between the steroid levels of conditioned and nonconditioned animals supplied with plain water or those that remained deprived, although deprivation increased corticosterone levels. Nonconditioned rats presented with saccharin had steroid levels that did not differ from control values. Conditioned animals presented with saccharin showed an elevation in steroid level which was significantly greater than that observed in any other group. Comparable results were obtained when LiCl was used as the unconditioned stimulus.
引用
收藏
页码:1156 / 1163
页数:8
相关论文
共 30 条
[11]  
DICARA LV, 1970, SCI AM, V222, P31
[12]   PLASMA CORTICOSTERONE RESPONSE TO PARAMETERS OF ELECTRIC SHOCK STIMULATION IN RAT [J].
FRIEDMAN, SB ;
ADER, R ;
GROTA, LJ ;
LARSON, T .
PSYCHOSOMATIC MEDICINE, 1967, 29 (04) :323-&
[13]   FLUOROMETRIC DETERMINATION OF CORTICOSTERONE + CORTISOL IN 0.02-0.05 MILLILITERS OF PLASMA OR SUBMILLIGRAM SAMPLES OF ADRENAL TISSUE [J].
GLICK, D ;
LEVINE, S ;
VONREDLICH, D .
ENDOCRINOLOGY, 1964, 74 (04) :653-&
[14]   ANIMAL LEARNING - VISCERAL AND AUTONOMIC CONDITIONING [J].
HARRIS, AH ;
BRADY, JV .
ANNUAL REVIEW OF PSYCHOLOGY, 1974, 25 :107-133
[15]   ADRENAL-PITUITARY INFLUENCE IN REACTIVATION OF AVOIDANCE-LEARNING MEMORY IN RAT AFTER INTERMEDIATE INTERVALS [J].
KLEIN, SB .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1972, 79 (03) :341-&
[16]   REACTIVATION OF AVOIDANCE-LEARNING MEMORY IN RAT AFTER INTERMEDIATE RETENTION INTERVALS [J].
KLEIN, SB ;
SPEAR, NE .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1970, 72 (03) :498-&
[17]   FOOD AND WATER RESTRICTION SHIFTS CORTICOSTERONE, TEMPERATURE, ACTIVITY AND BRAIN AMINE PERIODICITY [J].
KRIEGER, DT .
ENDOCRINOLOGY, 1974, 95 (05) :1195-1201
[18]   HORMONAL INFLUENCES ON BRAIN ORGANIZATION IN INFANT RATS [J].
LEVINE, S ;
MULLINS, RF .
SCIENCE, 1966, 152 (3729) :1585-+
[19]   ADRENOCORTICOTROPIC HORMONE (ACTH) AND PASSIVE AVOIDANCE LEARNING [J].
LEVINE, S ;
JONES, LE .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1965, 59 (03) :357-&
[20]  
Mason J W, 1966, Res Publ Assoc Res Nerv Ment Dis, V43, P227