REGENERATION AND DOSE-RESPONSE CHARACTERISTICS OF IRRADIATED MOUSE DORSAL EPIDERMAL-CELLS

被引：63

作者：

ALBARWARI, SE ^{[1
]}

POTTEN, CS ^{[1
]}

机构：

[1] CHRISTIE HOSP & HOLT RADIUM INST, PATERSON LABS, MANCHESTER M20 9BX, ENGLAND

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1976年 / 30卷 / 03期

关键词：

D O I：

10.1080/09553007614550981

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A microcolony technique is described for measuring epidermal cell survival 3 days after whole-body X-irradiation. This assay provides a cell D0 [lethal dose] value of 233 .+-. 11 rad and a zero-dose extrapolate of 1.23 .times. 104 cells/cm2 for mice irradiated in O2 20 h after hair plucking. The microcolony cellularity had an apparent doubling-time of 25 h which may be an upper limit at least for some clones. The clones appeared to fragment continually and form new daughter clones, suggesting that few would form macroscopic nodules. Many of the clones were also apparently associated with hair follicles.

引用

页码：201 / 216

页数：16

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