INDUCTION OF HEAT-SHOCK PROTEIN-70 AND GLIAL FIBRILLARY ACIDIC PROTEIN IN THE POSTISCHEMIC GERBIL HIPPOCAMPUS

被引：5

作者：

ARAKI, T

KATO, H

LIU, XH

KOGURE, K

ITOYAMA, Y

机构：

[1] FDN BRAIN & NERVE DIS,KUMAGAYA,JAPAN

[2] INST NEUROPATHOL,KUMAGAYA,JAPAN

来源：

METABOLIC BRAIN DISEASE | 1994年 / 9卷 / 04期

关键词：

CEREBRAL ISCHEMIA; HIPPOCAMPUS; HEAT SHOCK PROTEIN 70; ASTROCYTE; IMMUNOHISTOCHEMISTRY; GERBIL;

D O I：

10.1007/BF02098883

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunohistochemical changes of heat shock protein 70 (HSP 70) and glial fibrillary acidic protein (GFAP) were investigated in the gerbil hippocampus 1 h-7 days after 10 min of cerebral ischemia. Transient cerebral ischemia caused HSP 70 expression in GFAP-positive astrocytes in a delayed fashion, as compared with a rapid induction in vulnerable neurons such as hilar neurons. The present results may offer clues to elucidate the mechanisms of ischemic neuronal damage.

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页码：369 / 375

页数：7

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