HIGH-RESOLUTION DISTRIBUTION OF MESSENGER-RNA WITHIN THE CYTOSKELETON

被引：31

作者：

BASSELL, GJ ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,MED CTR,DEPT CELL BIOL,WORCESTER,MA 01655

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 1993年 / 52卷 / 02期

关键词：

CYTOSKELETON; INSITU HYBRIDIZATION; MESSENGER RNA LOCALIZATION; MESSENGER RNA-CYTOSKELETAL INTERACTION;

D O I：

10.1002/jcb.240520203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been well documented that mRNA is associated with the cytoskeleton, and that this relationship is involved in translation and mRNA sorting. The molecular components involved in the attachment of mRNA to the cytoskeleton are only poorly understood. The objective of this research was to directly visualize the interaction of mRNA with the cytoskeleton, with sufficient resolution to identify the filament systems involved. This work required the development of novel in situ hybridization methods for use with electron microscopy.

引用

页码：127 / 133

页数：7

共 26 条

[1]

BASSELL GJ, 1992, ELECTRON MICROSCOPY

[2] MESSENGER-RNA IS TRANSLATED WHEN ASSOCIATED WITH THE CYTOSKELETAL FRAMEWORK IN NORMAL AND VSV-INFECTED HELA-CELLS [J].

CERVERA, M ;

DREYFUSS, G ;

PENMAN, S .

CELL, 1981, 23 (01) :113-120

[3] SYNTHESIS AND INCORPORATION OF MYELIN POLYPEPTIDES INTO CNS MYELIN [J].

COLMAN, DR ;

KREIBICH, G ;

FREY, AB ;

SABATINI, DD .

JOURNAL OF CELL BIOLOGY, 1982, 95 (02) :598-608

[4] ALTERED TRANSLATABILITY OF MESSENGER-RNA FROM SUSPENDED ANCHORAGE-DEPENDENT FIBROBLASTS - REVERSAL UPON CELL ATTACHMENT TO A SURFACE [J].

FARMER, SR ;

BENZEEV, A ;

BENECKE, BJ ;

PENMAN, S .

CELL, 1978, 15 (02) :627-637

[5] DETECTION OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR ALPHA-SUBUNIT MESSENGER-RNA BY INSITU HYBRIDIZATION AT NEUROMUSCULAR-JUNCTIONS OF 15-DAY-OLD CHICK STRIATED MUSCLES [J].

FONTAINE, B ;

SASSOON, D ;

BUCKINGHAM, M ;

CHANGEUX, JP .

EMBO JOURNAL, 1988, 7 (03) :603-609

[6] STRUCTURE OF THE SEGMENTATION GENE PAIRED AND THE DROSOPHILA PRD GENE SET AS PART OF A GENE NETWORK [J].

FRIGERIO, G ;

BURRI, M ;

BOPP, D ;

BAUMGARTNER, S ;

NOLL, M .

CELL, 1986, 47 (05) :735-746

[7] THE SPATIAL-DISTRIBUTION OF POLYRIBOSOMES IN 3T3-CELLS AND THE ASSOCIATED ASSEMBLY OF PROTEINS INTO THE SKELETAL FRAMEWORK [J].

FULTON, AB ;

WAN, KM ;

PENMAN, S .

CELL, 1980, 20 (03) :849-857

[8] SELECTIVE LOCALIZATION OF MESSENGER-RNA FOR CYTOSKELETAL PROTEIN MAP2 IN DENDRITES [J].

GARNER, CC ;

TUCKER, RP ;

MATUS, A .

NATURE, 1988, 336 (6200) :674-677

[9] Actin-binding proteins [J].

Hartwig, John H. ;

Kwiatkowski, David J. .

CURRENT OPINION IN CELL BIOLOGY, 1991, 3 (01) :87-97

[10]

HESKETH JE, 1991, BIOCHEM J, V277, P1

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