REGULATION OF HIPPOCAMPAL TRANSMITTER RELEASE DURING DEVELOPMENT AND LONG-TERM POTENTIATION

被引：306

作者：

BOLSHAKOV, VY ^{[1
]}

SIEGELBAUM, SA ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG, HOWARD HUGHES MED INST, NEW YORK, NY 10032 USA

来源：

SCIENCE | 1995年 / 269卷 / 5231期

关键词：

D O I：

10.1126/science.7569903

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Developmental changes in rat hippocampal transmitter release and synaptic plasticity were investigated. Recordings from pairs of pyramidal neurons in slices showed that an action potential in a CA3 neuron released only a single quantum of transmitter onto a CAI neuron. Failures of synaptic transmission reflected probabilistic transmitter release. The probability of release (P-r) was 0.9 in 4- to 8-day-old rats and decreased to less than 0.5 at 2 to 3 weeks. Long-term potentiation (LTP) in 2- to 3-week-old rats was associated with an increase in P-r from a single synaptic site. The high initial P-r in 4- to 8-day-old rats normally occludes the expression of LTP at this stage.

引用

页码：1730 / 1734

页数：5

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