PROTECTION FROM FAS-MEDIATED APOPTOSIS BY A SOLUBLE FORM OF THE FAS MOLECULE

被引：1077

作者：

CHENG, JH

ZHOU, T

LIU, CD

SHAPIRO, JP

BRAUER, MJ

KIEFER, MC

BARR, PJ

MOUNTZ, JD

机构：

[1] UNIV ALABAMA,BIRMINGHAM,AL 35294

[2] VET ADM MED CTR,BIRMINGHAM,AL 35294

[3] LXR BIOTECHNOL INC,RICHMOND,CA 94804

来源：

SCIENCE | 1994年 / 263卷 / 5154期

关键词：

D O I：

10.1126/science.7510905

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fas is an apoptosis-signaling receptor molecule on the surface of a number of cell types. Molecular cloning and nucleotide sequence analysis revealed a human Fas messenger RNA variant capable of encoding a soluble Fas molecule lacking the transmembrane domain because of the deletion of an exon encoding this region. The expression of soluble Fas was confirmed by flow cytometry and immunocytochemical analysis. Supernatants from cells transfected with the variant messenger RNA blocked apoptosis induced by the antibody to Fas. Levels of soluble Fas were elevated in patients with systemic lupus erythematosus, and mice injected with soluble Fas displayed autoimmune features.

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页码：1759 / 1762

页数：4

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