MRI CHARACTERIZATION OF DIFFUSION-COEFFICIENTS IN A RAT SPINAL-CORD INJURY MODEL

被引：143

作者：

FORD, JC ^{[1
]}

HACKNEY, DB ^{[1
]}

ALSOP, DC ^{[1
]}

JARA, H ^{[1
]}

JOSEPH, PM ^{[1
]}

HAND, CM ^{[1
]}

BLACK, P ^{[1
]}

机构：

[1] HAHNEMANN UNIV,DEPT NEUROSURG,PHILADELPHIA,PA 19102

来源：

MAGNETIC RESONANCE IN MEDICINE | 1994年 / 31卷 / 05期

关键词：

DIFFUSION; MAGNETIC RESONANCE IMAGING; SPINAL CORD INJURIES;

D O I：

10.1002/mrm.1910310504

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Apparent diffusion coefficients (ADC) were measured in a rat spinal cord weight-drop injury model. After sacrifice, the spinal cords were fixed in situ and excised for MR imaging and ADC measurement. Diffusion is anisotropic in normal gray and white matter. There were significant decreases in ADCs measured along the longitudinal axis of the injured cord and increases in ADCs measured transverse to the cord. Injured segments demonstrated reductions in diffusion anisotropy in the white matter. Diffusion was completely isotropic at the epicenter of the weight drop injury. Significant decreases in longitudinal ADC and increases in transverse ADC were observed in portions of the cord which appeared normal on conventional spin-echo and calculated T-2 images. Thus ADC measurement may complement routine imaging for evaluation of spinal cord injury.

引用

页码：488 / 494

页数：7

共 47 条

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