14,15-EPOXYEICOSATRIENOIC ACID PROMOTES ENDOTHELIAL-CELL DEPENDENT ADHESION OF HUMAN MONOCYTIC TUMOR U937 CELLS

被引：38

作者：

PRITCHARD, KA ^{[1
]}

TOTA, RR ^{[1
]}

STEMERMAN, MB ^{[1
]}

WONG, PYK ^{[1
]}

机构：

[1] NEW YORK MED COLL,DEPT MED,VALHALLA,NY 10595

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91741-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arachidonic acid (AA) can be metabolized in endothelial cells (EC) to a series of epoxides via cytochrome P-450 epoxygenase with 14,15 epoxyeicosatrienoic acid (14,15-EET) as the major product. In this communication we report that 14,15-EET significantly enhances U937 cell attachment to EC with maximal cell attachment at 2.5 to 5 × 10-7M 14,15-EET. Thus, 14,15-EET may play a substantial role in inflammation and/or atherogenesis by inducing monocyte attachment to EC. © 1990.

引用

页码：137 / 142

页数：6

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