HCAP-18, A CATHELIN/PRO-BACTENECIN-LIKE PROTEIN OF HUMAN NEUTROPHIL SPECIFIC GRANULES

被引：283

作者：

COWLAND, JB

JOHNSEN, AH

BORREGAARD, N

机构：

[1] RIGSHOSP, DEPT HEMATOL, GRANULOCYE RES LAB, DK-2100 COPENHAGEN, DENMARK

[2] RIGSHOSP, DEPT CLIN BIOCHEM, DK-2100 COPENHAGEN, DENMARK

来源：

FEBS LETTERS | 1995年 / 368卷 / 01期

关键词：

CAP-18; CDNA; NEUTROPHIL; FALL-39; CATHELIN;

D O I：

10.1016/0014-5793(95)00634-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 19 kDa protein was identified in specific granules of human neutrophils, A full-length cDNA clone was isolated from a human CML cDNA library, based on amino-acid sequences of isolated tryptic fragments, This clone includes the recently identified cDNA for FALL-39/CAP-18. Aminoacid sequences of proteolytic fragments derived both from the conserved N-terminal cathelin-like region and the highly variable C-terminal region characteristic of this family of bactericidal, LPS binding proteins, were in complete agreement with the sequence deduced from the cDNA, Thus, the 19 kDa protein is hCAP-18, stored as a 'pro-peptide' in specific granules.

引用

页码：173 / 176

页数：4

共 33 条

[1] FALL-39, A PUTATIVE HUMAN PEPTIDE ANTIBIOTIC, IS CYSTEINE-FREE AND EXPRESSED IN BONE-MARROW AND TESTIS [J].