DETECTION OF ENDOGENOUS MALONDIALDEHYDE-DEOXYGUANOSINE ADDUCTS IN HUMAN LIVER

被引：408

作者：

CHAUDHARY, AK

NOKUBO, M

REDDY, GR

YEOLA, SN

MORROW, JD

BLAIR, IA

MARNETT, LJ

机构：

[1] VANDERBILT UNIV,SCH MED,AB HANCOCK JR MEM LAB CANC RES,NASHVILLE,TN 37232

[2] VANDERBILT UNIV,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

[3] VANDERBILT UNIV,SCH MED,DEPT PHARMACOL,NASHVILLE,TN 37232

来源：

SCIENCE | 1994年 / 265卷 / 5178期

关键词：

D O I：

10.1126/science.8079172

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens.

引用

页码：1580 / 1582

页数：3

共 31 条

[1] ENDOGENOUS MUTAGENS AND THE CAUSES OF AGING AND CANCER [J].