PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A CYCLIC NUCLEOTIDE-GATED CHANNEL FROM RABBIT AORTA

被引：67

作者：

BIEL, M

ALTENHOFEN, W

HULLIN, R

LUDWIG, J

FREICHEL, M

FLOCKERZI, V

DASCAL, N

KAUPP, UB

HOFMANN, F

机构：

[1] TECH UNIV MUNICH, INST PHARMAKOL & TOXIKOL, BIEDERSTEINERSTR 29, D-80802 MUNICH, GERMANY

[2] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, INST BIOL INFORMAT VERARBEITUNG, W-5170 JULICH 1, GERMANY

[3] TEL AVIV UNIV, SACKLER SCH MED, DEPT PHYSIOL & PHARMACOL, IL-69978 TEL AVIV, ISRAEL

来源：

FEBS LETTERS | 1993年 / 329卷 / 1-2期

关键词：

CYCLIC NUCLEOTIDE-GATED CHANNEL; AORTA; PRIMARY STRUCTURE; EXPRESSION;

D O I：

10.1016/0014-5793(93)80209-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sino-atrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.

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页码：134 / 138

页数：5

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