ENDOCYTOSIS OF GROWTH-FACTOR RECEPTORS

被引:243
作者
SORKIN, A [1 ]
WATERS, CM [1 ]
机构
[1] VANDERBILT UNIV, SCH MED, DEPT BIOMED ENGN, NASHVILLE, TN 37232 USA
关键词
D O I
10.1002/bies.950150603
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Binding of a growth factor (GF) to its specific receptor on the cell surface causes the initiation of a signal transduction cascade which eventually results in mitosis. GF:receptor complexes are removed from the cell surface via receptor-mediated endocytosis, a process which involves clathrin-coated pits. After internalization into the endosomal compartment, a significant pool of GFs and GF receptors escape recycling to the cell surface and are sorted to the degradation pathway. The ligand-induced internalization and lysosomal degradation of GF receptors result in the dramatic loss of surface receptors, a phenomenon termed receptor down-regulation. In this review, we discuss relevant biochemical, morphological and kinetic studies of the mechanism of GF endocytosis, and the possible role of this process in mitogenic signaling by growth factor receptors.
引用
收藏
页码:375 / 382
页数:8
相关论文
共 56 条
[1]   DOWN-REGULATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN KB CELLS IS DUE TO RECEPTOR INTERNALIZATION AND SUBSEQUENT DEGRADATION IN LYSOSOMES [J].
BEGUINOT, L ;
LYALL, RM ;
WILLINGHAM, MC ;
PASTAN, I .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (08) :2384-2388
[2]  
BOONSTRA J, 1985, EUR J CELL BIOL, V36, P209
[3]   THE ROLE OF KINASE-ACTIVITY AND THE KINASE INSERT REGION IN LIGAND-INDUCED INTERNALIZATION AND DEGRADATION OF THE C-FMS PROTEIN [J].
CARLBERG, K ;
TAPLEY, P ;
HAYSTEAD, C ;
ROHRSCHNEIDER, L .
EMBO JOURNAL, 1991, 10 (04) :877-883
[4]   I125 LABELED HUMAN EPIDERMAL GROWTH-FACTOR - BINDING, INTERNALIZATION, AND DEGRADATION IN HUMAN FIBROBLASTS [J].
CARPENTER, G ;
COHEN, S .
JOURNAL OF CELL BIOLOGY, 1976, 71 (01) :159-171
[5]  
CARPENTER G, 1987, ANNU REV BIOCHEM, V56, P881, DOI 10.1146/annurev.bi.56.070187.004313
[6]   DIRECT VISUALIZATION OF THE PHOSPHORYLATED EPIDERMAL GROWTH-FACTOR RECEPTOR DURING ITS INTERNALIZATION IN A-431 CELLS [J].
CARPENTIER, JL ;
WHITE, MF ;
ORCI, L ;
KAHN, RC .
JOURNAL OF CELL BIOLOGY, 1987, 105 (06) :2751-2762
[7]   CO-LOCALIZATION OF I-125 EPIDERMAL GROWTH-FACTOR AND FERRITIN-LOW DENSITY LIPOPROTEIN IN COATED PITS - A QUANTITATIVE ELECTRON-MICROSCOPIC STUDY IN NORMAL AND MUTANT HUMAN-FIBROBLASTS [J].
CARPENTIER, JL ;
GORDEN, P ;
ANDERSON, RGW ;
GOLDSTEIN, JL ;
BROWN, MS ;
COHEN, S ;
ORCI, L .
JOURNAL OF CELL BIOLOGY, 1982, 95 (01) :73-77
[8]  
CHANG CP, 1991, J BIOL CHEM, V266, P23467
[9]   FUNCTIONAL INDEPENDENCE OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR FROM A DOMAIN REQUIRED FOR LIGAND-INDUCED INTERNALIZATION AND CALCIUM REGULATION [J].
CHEN, WS ;
LAZAR, CS ;
LUND, KA ;
WELSH, JB ;
CHANG, CP ;
WALTON, GM ;
DER, CJ ;
WILEY, HS ;
GILL, GN ;
ROSENFELD, MG .
CELL, 1989, 59 (01) :33-43
[10]  
COHEN S, 1985, J BIOL CHEM, V260, P2351