DOES THE HYPOXIC VENTILATORY RESPONSE PREDICT THE OXYGEN-INDUCED FALLS IN VENTILATION IN COPD

被引：6

作者：

BERRY, RB ^{[1
]}

MAHUTTE, CK ^{[1
]}

KIRSCH, JL ^{[1
]}

LIGHT, RW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,IRVINE,CA 92717

来源：

CHEST | 1993年 / 103卷 / 03期

关键词：

D O I：

10.1378/chest.103.3.820

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The purpose of this study was to determine whether supplemental oxygen-induced decreases in ventilation (VE) and mouth occlusion pressure (P0.1) in patients with COPD are related to the ventilatory or P0.1 responses to hypoxia (DELTAVE/DELTASaO2, DELTAP0.1/DELTASaO2). We measured these responses in 14 patients with a (mean+/-SD) FEV1 of 0.95+/-.41 L. The VE and P0.1 were al so measured while the patients sequentially breathed either room air or supplemental oxygen (1-2 L/min) for 10 min in a randomized single blind fashion. The mean (+/-SEM) SaO2 increased from 90.8+/-0.99 percent to 95.2+/-0.46 percent and the VE decreased during oxygen breathing from 12.3+/-0.46 to 11.6+/-0.47 L/min (p<0.03). However, the individual changes in VE were not significantly related to the corresponding changes in SaO2 (CHG SaO2), (DELTAVE/DELTASaO2), or (DELTAVE/SaO2) (CHG SaO2). Similarly, the P0.1 decreased from 2.50+/-0.27 to 2.26+/-0.20 cm H2O (p<0.05), but the individual changes in P0.1 were not significantly related to (CHG SaO2), (DELTAP0.1/DELTASaO2), or (DELTAP0.1/DELTASaO2) (CHG SaO2).

引用

页码：820 / 824

页数：5

共 15 条

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[2]

BYE PTP, 1985, AM REV RESPIR DIS, V132, P236

[3] VENTILATORY MUSCLE RECRUITMENT IN EXERCISE WITH O-2 IN OBSTRUCTED PATIENTS WITH MILD HYPOXEMIA [J].