EFFECTS OF 6-HYDROXYDOPAMINE-INDUCED LESIONS OF THE PARAVENTRICULAR NUCLEUS, AND OF PRAZOSIN, ON THE CORTICOSTERONE RESPONSE TO RESTRAINT IN RATS

被引：60

作者：

GIBSON, A ^{[1
]}

HART, SL ^{[1
]}

PATEL, S ^{[1
]}

机构：

[1] UNIV LONDON CHELSEA COLL, DEPT PHARMACOL, MANRESA RD, LONDON SW3 6LX, ENGLAND

来源：

NEUROPHARMACOLOGY | 1986年 / 25卷 / 03期

关键词：

D O I：

10.1016/0028-3908(86)90248-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In rats, with bilateral lesions of the paraventricular nuclei induced by 6-hydroxydopamine, restraint stress failed to elevate levels of corticosterone in plasma, although the resting levels in lesioned animals were similar to those of control rats. Prazosin inhibited the plasma-corticosterone response to restraint in intact rats, at doses which did not by themselves influence resting hormone levels. These results suggest a positive role for noradrenaline, acting through .alpha.-adrenoceptors, on the stress-induced output of corticotrophin.

引用

页码：257 / 260

页数：4

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