LONG-TERM POTENTIATION OF HIPPOCAMPAL SYNAPTIC TRANSMISSION AFFECTS RATE OF BEHAVIORAL LEARNING

被引：218

作者：

BERGER, TW ^{[1
]}

机构：

[1] UNIV PITTSBURGH, DEPT PSYCHIAT, PROGRAM PSYCHOBIOL, PITTSBURGH, PA 15260 USA

来源：

SCIENCE | 1984年 / 224卷 / 4649期

关键词：

D O I：

10.1126/science.6324350

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Electrical stimulation techniques were used to produce a long-lasting potentiation of synaptic transmission in the hippocampus of naive rabbits. Animals were then classically conditioned. Long-term potentiation of the hippocampus before training increased the rate at which animals subsequently learned the conditioning task. This result has significance for potential cellular mechanisms of associative learning.

引用

页码：627 / 630

页数：4

共 73 条

[1]

Agranoff B., 1978, PSYCHOPHARMACOLOGY G, P623

[2] LONG-TERM AND SHORT-TERM PLASTICITY IN CA1, CA3, AND DENTATE REGIONS OF RAT HIPPOCAMPAL SLICE [J].

ALGER, BE ;

TEYLER, TJ .

BRAIN RESEARCH, 1976, 110 (03) :463-480

[3] POTASSIUM AND SHORT-TERM RESPONSE PLASTICITY IN THE HIPPOCAMPAL SLICE [J].

ALGER, BE ;

TEYLER, TJ .

BRAIN RESEARCH, 1978, 159 (01) :239-242

[4] A COMPARISON OF DISTAL AND PROXIMAL DENDRITIC SYNAPSES OF CAI PYRAMIDS IN GUINEA-PIG HIPPOCAMPAL SLICES INVITRO [J].

ANDERSEN, P ;

SILFVENIUS, H ;

SUNDBERG, SH ;

SVEEN, O .

JOURNAL OF PHYSIOLOGY-LONDON, 1980, 307 (OCT) :273-&

[5] ENTORHINAL ACTIVATION OF DENTATE GRANULE CELLS [J].

ANDERSEN, P ;

HOLMQVIST, B ;

VOORHOEVE, PE .

ACTA PHYSIOLOGICA SCANDINAVICA, 1966, 66 (04) :448-+

[6]

ANDERSEN P, 1980, J PHYSIOL-LONDON, V302, P463

[7]

ANDERSEN P, 1971, EXP BRAIN RES, V13, P222

[8] SPECIFIC LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN HIPPOCAMPAL SLICES [J].

ANDERSEN, P ;

SUNDBERG, SH ;

SVEEN, O ;

WIGSTROM, H .

NATURE, 1977, 266 (5604) :736-737

[9] HYPOTHESIS REGARDING THE CELLULAR MECHANISMS RESPONSIBLE FOR LONG-TERM SYNAPTIC POTENTIATION IN THE HIPPOCAMPUS [J].

BAUDRY, M ;

LYNCH, G .

EXPERIMENTAL NEUROLOGY, 1980, 68 (01) :202-204

[10] IDENTIFICATION OF PYRAMIDAL CELLS AS CRITICAL ELEMENTS IN HIPPOCAMPAL NEURONAL PLASTICITY DURING LEARNING [J].

BERGER, TW ;

THOMPSON, RF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (03) :1572-1576

← 1 2 3 4 5 6 7 8 →