LONG-TERM POTENTIATION OF HIPPOCAMPAL SYNAPTIC TRANSMISSION AFFECTS RATE OF BEHAVIORAL LEARNING

被引:218
作者
BERGER, TW [1 ]
机构
[1] UNIV PITTSBURGH, DEPT PSYCHIAT, PROGRAM PSYCHOBIOL, PITTSBURGH, PA 15260 USA
关键词
D O I
10.1126/science.6324350
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Electrical stimulation techniques were used to produce a long-lasting potentiation of synaptic transmission in the hippocampus of naive rabbits. Animals were then classically conditioned. Long-term potentiation of the hippocampus before training increased the rate at which animals subsequently learned the conditioning task. This result has significance for potential cellular mechanisms of associative learning.
引用
收藏
页码:627 / 630
页数:4
相关论文
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