ACTIONS OF DRUGS ON SINGLE NEURONS IN CATS RETINA

被引:89
作者
STRASCHILL, M
机构
[1] Department of Physiology, University of California Medical Center, San Francisco
关键词
D O I
10.1016/0042-6989(68)90062-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of intraarterially and intravenously injected drugs on spontaneous and light-driven activity was investigated in 300 single retinal units. Neurons were excited by strychnine, l-glutamate, noradrenaline, d-amphetamine, acetylcholine and eserine. Strychnine did not abolish light-induced inhibition. Depression of activity was observed after gaba, serotonine, ergometrine, d-amphetamine, noradrenaline and acetylcholine. Cholinolytic and adrenolytic substances blocked the effect of injected acetylcholine resp. noradrenaline and d-phetamine, but did not influence normal spontanous or light-driven activity. Reserpine had no effect on light-inducted inhibitory and excitatory reactions. It is therefore concluded, that neither acetylcholine nor noradrenaline are the main and only transmitters of retinal excitation or inhibition. © 1968.
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页码:35 / +
页数:1
相关论文
共 25 条
[1]   STRYCHNINE-RESISTANT INHIBITION IN BRAIN [J].
ANDERSEN, P ;
LOYNING, Y ;
VOORHOEVE, PE ;
ECCLES, JC .
NATURE, 1963, 200 (490) :843-&
[2]  
BISHOP PO, 1957, J NEUROPHYSIOL, V21, P529
[3]  
BOGDANSKI D, 1961, J PHARMACOL EXP THER, V132, P176
[4]  
Bradley P.B., 1958, ARCH ITAL BIOL, V96, P168
[5]  
BRADLEY PB, 1965, BR MED B, V21
[7]  
BROWN KT, 1959, J PHYSIOL-LONDON, V149, P573
[8]  
CRAWFORD JM, 1963, NATURE, V200, P844
[9]   PHARMACOLOGICAL STUDIES UPON NEURONES OF LATERAL GENICULATE NUCLEUS OF CAT [J].
CURTIS, DR ;
DAVIS, R .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1962, 18 (02) :217-&
[10]   ADRENERGIC MECHANISMS IN PUPILLARY LIGHT-REFLEX PATH [J].
DAHLSTROM, A ;
FUXE, K ;
MALMFORS, T ;
HILLARP, NA .
ACTA PHYSIOLOGICA SCANDINAVICA, 1964, 62 (1-2) :119-&