USE OF TWIN COHORTS FOR RESEARCH IN ALZHEIMERS-DISEASE

被引：32

作者：

BREITNER, JCS

GATZ, M

BERGEM, ALM

CHRISTIAN, JG

MORTIMER, JA

MCCLEARN, GE

HESTON, LL

WELSH, KA

ANTHONY, JC

FOLSTEIN, MF

RADEBAUGH, TS

机构：

[1] DUKE UNIV, MED CTR, KATHLEEN BRYAN ALZHEIMERS DIS RES CTR, DURHAM, NC 27710 USA

[2] VET ADM MED CTR, CTR GERIATR RES EDUC & CLIN, MINNEAPOLIS, MN USA

[3] WASHINGTON INST MENTAL ILLNESS RES & TRAINING, FT STEILACOOM, WA USA

[4] UNIV MINNESOTA, DEPT NEUROL, MINNEAPOLIS, MN 55455 USA

[5] JOHNS HOPKINS UNIV, DEPT PSYCHIAT & BEHAV SCI, BALTIMORE, MD 21218 USA

[6] JOHNS HOPKINS UNIV, DEPT MENTAL HYG, BALTIMORE, MD 21218 USA

[7] UNIV SO CALIF, DEPT PSYCHOL, LOS ANGELES, CA 90089 USA

[8] NIA, BETHESDA, MD 20892 USA

[9] UNIV OSLO, DEPT PSYCHIAT, OSLO 3, NORWAY

[10] PENN STATE UNIV, COLL HLTH & HUMAN DEV, UNIV PK, PA 16802 USA

[11] INDIANA UNIV, SCH MED, DEPT MED & MOLEC GENET, INDIANAPOLIS, IN 46202 USA

来源：

NEUROLOGY | 1993年 / 43卷 / 02期

关键词：

D O I：

10.1212/WNL.43.2.261

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The causes of Alzheimer's disease (AD) remain a mystery despite the recent identification of several putative environmental risk factors and the discovery of several linked genetic loci and point mutations associated with the disease. Particularly uncertain is the generalizability of the genetic findings to the common forms of disease encountered in clinical practice or population research. Twin studies of AD can illuminate causal mechanisms, both genetic and environmental. This consensus document explores the rationale for such twin studies, as well as a number of methodologic problems that render them difficult to implement or interpret. We review existing twin studies of AD and note several ambitious new studies. Finally, we delineate several practical strategies for the near future of twin research in AD.

引用

页码：261 / 267

页数：7

共 91 条

[1] RISK-FACTORS FOR CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE - A CASE-CONTROL STUDY OF AN ITALIAN POPULATION [J].