INOSITOL 6 G DAILY MAY BE EFFECTIVE IN DEPRESSION BUT NOT IN SCHIZOPHRENIA

被引：36

作者：

LEVINE, J

GONSALVES, M

BABUR, I

STIER, S

ELIZUR, A

KOFMAN, O

BELMAKER, RH

机构：

[1] BEN GURION UNIV NEGEV,FAC HIST SCI,DIV PSYCHIAT,IL-84105 BEER SHEVA,ISRAEL

[2] TEL AVIV UNIV,ABARBANEL MENTAL HLTH CTR,IL-69978 TEL AVIV,ISRAEL

[3] BEN GURION UNIV NEGEV,FAC HIST SCI,MINIST HLTH,MENTAL HLTH CTR,IL-84105 BEER SHEVA,ISRAEL

[4] TEL AVIV UNIV,DIV PSYCHIAT,IL-69978 TEL AVIV,ISRAEL

来源：

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 1993年 / 8卷 / 01期

关键词：

INOSITOL; DEPRESSION; SCHIZOPHRENIA;

D O I：

10.1002/hup.470080109

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Inositol is an important precursor for second messenger synthesis and has been reported to be reduced by lithium treatment in rat brain and in human CSF in depression. An open trial of 6 g/day in 11 depressed patients resistant to previous treatment led to major improvement in nine patients. The enzyme synthesizing inositol has been reported to be elevated in schizophrenia, suggesting an attempted compensation for possible inositol deficiency. A controlled double-blind crossover trial in 10 chronic schizophrenic patients of 6 g/day of inositol for 30 days did not reveal any benefit.

引用

页码：49 / 53

页数：5

共 17 条

[1] HIGH-DOSE DIETARY MYOINOSITOL SUPPLEMENTATION DOES NOT ALTER THE ISCHEMIA PHENOMENON IN HUMAN DIABETICS [J].