EXPRESSION OF THE RAG-2 GENE IN MURINE CENTRAL-NERVOUS-SYSTEM TUMOR-CELL LINES

被引:8
作者
AOKI, T
TASHIRO, K
MIYATAKE, S
NAKANO, T
ODA, Y
KIKUCHI, H
HONJO, T
机构
[1] Department of Neurosurgery and Medical Chemistry, Faculty of Medicine, Kyoto University, Kyoto, 606, Sakyo ku
关键词
D O I
10.1016/S0006-291X(05)81394-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two tightly linked recombination activating genes, RAG-1 and RAG-2, are involved in VDJ recombination of the immune system. Although these genes were originally thought to be expressed exclusively in precursor B and T cells, RAG-1 transcripts were recently found in the murine central nervous system(CNS)[Chun et al., Cell 6, 189, (1991)]. We found that the RAG-2 gene was expressed in CNS tumor cell lines, melanoma(B-16) and skin fibroblast(A9). RAG-1 expression was not found in any non-lymphoid cell lines examined including CNS tumor cell lines. Another VDJ recombination-related gene RBP Jκ was expressed in all tumor cell lines examined. It remains to be seen whether expression of RAG-1 and RAG-2 in CNS is abortive or functionally important. © 1991 Academic Press, Inc.
引用
收藏
页码:151 / 158
页数:8
相关论文
共 26 条
[1]   ORGANIZATION AND REORGANIZATION OF IMMUNOGLOBULIN GENES IN A-MULV TRANSFORMED-CELLS - REARRANGEMENT OF HEAVY BUT NOT LIGHT CHAIN GENES [J].
ALT, F ;
ROSENBERG, N ;
LEWIS, S ;
THOMAS, E ;
BALTIMORE, D .
CELL, 1981, 27 (02) :381-390
[2]   THE MOUSE MUTATION SEVERE COMBINED IMMUNE-DEFICIENCY (SCID) IS ON CHROMOSOME-16 [J].
BOSMA, GC ;
DAVISSON, MT ;
RUETSCH, NR ;
SWEET, HO ;
SHULTZ, LD ;
BOSMA, MJ .
IMMUNOGENETICS, 1989, 29 (01) :54-57
[3]   SELECTIVE EXPRESSION OF RAG-2 IN CHICKEN B-CELLS UNDERGOING IMMUNOGLOBULIN GENE CONVERSION [J].
CARLSON, LM ;
OETTINGER, MA ;
SCHATZ, DG ;
MASTELLER, EL ;
HURLEY, EA ;
MCCORMACK, WT ;
BALTIMORE, D ;
THOMPSON, CB .
CELL, 1991, 64 (01) :201-208
[4]   THE RECOMBINATION ACTIVATING GENE-1 (RAG-1) TRANSCRIPT IS PRESENT IN THE MURINE CENTRAL-NERVOUS-SYSTEM [J].
CHUN, JJM ;
SCHATZ, DG ;
OETTINGER, MA ;
JAENISCH, R ;
BALTIMORE, D .
CELL, 1991, 64 (01) :189-200
[5]  
DUNKAN LC, 1953, J NATL CANCER I, V13, P1299
[6]   THE IMMUNE LOGICAL BRAIN [J].
FARRAR, WL ;
HILL, JM ;
HARELBELLAN, A ;
VINOCOUR, M .
IMMUNOLOGICAL REVIEWS, 1987, 100 :361-378
[7]  
FILDER I, 1978, ADV CANCER RES, V28, P149
[8]  
FURUKAWA T, 1991, IN PRESS J BIOL CHEM
[9]  
GOETZL EJ, 1990, ADV IMMUNOL, V44, P1
[10]   PURIFICATION AND CHARACTERIZATION OF A PROTEIN THAT BINDS TO THE RECOMBINATION SIGNAL SEQUENCE OF THE IMMUNOGLOBULIN-J-ALEPH SEGMENT [J].
HAMAGUCHI, Y ;
MATSUNAMI, N ;
YAMAMOTO, Y ;
HONJO, T .
NUCLEIC ACIDS RESEARCH, 1989, 17 (22) :9015-9026