AN ALPHA/BETA-BARREL FULL OF EVOLUTIONARY TROUBLE

被引：92

作者：

FARBER, GK

机构：

[1] PENN STATE UNIV, DEPT MOLEC & CELL BIOL, UNIV PK, PA 16802 USA

[2] PENN STATE UNIV, CTR BIOMOLEC STRUCT & FUNC, UNIV PK, PA 16802 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(05)80114-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The eight-stranded alpha/beta-barrel (TIM barrel) is by far the most common shape for an enzyme: roughly one out of 10 enzymes have this domain. Three different evolutionary pathways have been proposed for this group of proteins. Recent work still cannot differentiate between the proposed pathways.

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页码：409 / 412

页数：4

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