MODULATION OF NEONATAL RAT HYPOGLOSSAL MOTONEURON EXCITABILITY BY SEROTONIN

被引：167

作者：

BERGER, AJ

BAYLISS, DA

VIANA, F

机构：

[1] Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle

来源：

NEUROSCIENCE LETTERS | 1992年 / 143卷 / 1-2期

关键词：

SEROTONIN; MOTONEURON; MEDULLA; NEUROTRANSMITTER; MODULATION; PATCH-CLAMP; RESPIRATION;

D O I：

10.1016/0304-3940(92)90257-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of 5-HT on neonatal rat hypoglossal motoneurons (HMs) were studied in two in vitro slice preparations. Serotonin caused either reversible depolarization or the generation of an inward current (I5-HT) in every cell tested. I5-HT persisted after synaptic blockade. In most of the cells tested, the magnitude of I5-HT was independent of membrane potential (-50 to -120 mV), and 5-HT had little effect on input resistance or slope conductance. In addition, 5-HT significantly reduced the amplitude of the post-spike medium-duration afterhyperpolarization. This reduction probably contributed to the resulting increase in the slope of the relationship describing the steady-state firing frequency response to injected current (f-I) observed in the presence of 5-HT. Thus, 5-HT increases the excitability of neonatal HMs via at least two different postsynaptic mechanisms.

引用

页码：164 / 168

页数：5

共 23 条

[1] INTRACELLULAR STUDIES IN THE FACIAL NUCLEUS ILLUSTRATING A SIMPLE NEW METHOD FOR OBTAINING VIABLE MOTONEURONS IN ADULT-RAT BRAIN-SLICES [J].