TRANSFORMATION OF NIH 3T3 CELLS BY OVEREXPRESSION OF THE NORMAL CODING SEQUENCE OF THE RAT NEU GENE

被引：82

作者：

DIMARCO, E ^{[1
]}

PIERCE, JH ^{[1
]}

KNICLEY, CL ^{[1
]}

DIFIORE, PP ^{[1
]}

机构：

[1] NCI,CELLULAR & MOLEC BIOL LAB,BLDG 37,ROOM 1E24,BETHESDA,MD 20892

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 06期

关键词：

D O I：

10.1128/MCB.10.6.3247

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While the normal human erbB-2 gene is potently transforming when overexpressed in NIH 3T3 cells, its rat homolog, the neu gene, seems to acquire transforming properties only upon alteration of its coding sequence. In this study, we compared the effects of different levels of expression of normal erbB-2 and neu in NIH 3T3 cells. Our results revealed that the normal rat neu gene acts as a potent oncogene when sufficiently overexpressed in NIH 3T3 cells.

引用

页码：3247 / 3252

页数：6

共 27 条

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