UBIQUITIN, A CENTRAL COMPONENT OF SELECTIVE CYTOPLASMIC PROTEOLYSIS, IS LINKED TO PROTEINS RESIDING AT THE LOCUS OF NONSELECTIVE PROTEOLYSIS, THE VACUOLE

被引：30

作者：

SIMEON, A

VANDERKLEI, IJ

VEENHUIS, M

WOLF, DH

机构：

[1] UNIV STUTTGART,INST BIOCHEM,PFAFFENWALDRING 55,W-7000 STUTTGART 80,GERMANY

[2] UNIV GRONINGEN,ELECTRON MICROSCOPY LAB,9751 NN HAREN,NETHERLANDS

来源：

FEBS LETTERS | 1992年 / 301卷 / 02期

关键词：

PROTEOLYSIS; UBIQUITIN; VACUOLE; LYSOSOME; YEAST; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/0014-5793(92)81254-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitin, an evolutionary highly conserved protein, is known to be involved in selective proteolysis in the cytoplasm. Here we show that ubiquitin-protein conjugates are also found in the yeast vacuole. Mutants defective in the major vacuolar endopeptidases, proteinase yscA and yscB, lead to accumulation of ubiquitin-protein conjugates in this cellular organelle.

引用

页码：231 / 235

页数：5

共 34 条

[1]

Achstetter T, 1985, Yeast, V1, P139, DOI 10.1002/yea.320010203

[2] UBIQUITIN PROTEIN CONJUGATES ACCUMULATE IN THE LYSOSOMAL SYSTEM OF FIBROBLASTS TREATED WITH CYSTEINE PROTEINASE-INHIBITORS [J].