CORTICOTROPIN-RELEASING HORMONE INDUCED SEIZURES IN INFANT RATS ORIGINATE IN THE AMYGDALA

被引：94

作者：

BARAM, TZ ^{[1
]}

HIRSCH, E ^{[1
]}

SNEAD, OC ^{[1
]}

SCHULTZ, L ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT NEUROL,LOS ANGELES,CA 90089

来源：

ANNALS OF NEUROLOGY | 1992年 / 31卷 / 05期

关键词：

D O I：

10.1002/ana.410310505

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin-releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days. Rat pups carried bipolar electrodes implanted in subcortical limbic structures, as well as cortical electrodes and intracerebroventricular cannulae. The administration of corticotropin-releasing hormone produced age-specific seizures within minutes, which correlated with rhythmic amygdala discharges. Paroxysmal hippocampal and cortical discharges developed subsequently in some rats. Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala.

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页码：488 / 494

页数：7

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