MODE OF FORMATION OF TETRAHYDRO-BETA-CARBOLINES

被引:36
作者
ROMMELSPACHER, H [1 ]
COPER, H [1 ]
STRAUSS, S [1 ]
机构
[1] FREE UNIV BERLIN, INST NEUROPSYCHOPHARMACOL, ULMENALLEE 30, D-1000 BERLIN, GERMANY
关键词
D O I
10.1016/0024-3205(76)90277-0
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The condensation of tetrahydro-.beta.-carboline (TBC) occurred if serotonin was incubated with 5-methyltetrahydrofolic acid and the cytosol fraction from rat brain as an enzymatic source. Such a formation occurred to a lesser extent if the enzyme(s) was omitted from the incubation mixture. The conditions of the enzymatic and non-enzymatic mode of formation of TBC were investigated. It was shown by addition of semicarbazide to the incubation medium that formaldehyde was an intermediate in the production of TBC. The biological significance of TBC was discussed.
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页码:81 / 88
页数:8
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