COPPER/ZINC SUPEROXIDE-DISMUTASE MESSENGER-RNA LEVELS ARE INCREASED IN SPORADIC AMYOTROPHIC-LATERAL-SCLEROSIS MOTOR-NEURONS

被引：51

作者：

BERGERON, C

MUNTASSER, S

SOMERVILLE, MJ

WEYER, L

PERCY, ME

机构：

[1] UNIV TORONTO,DEPT PATHOL,TORONTO M5S 1A8,ON,CANADA

[2] TORONTO HOSP,WESTERN DIV,DEPT PATHOL,TORONTO M5T 2S8,ON,CANADA

[3] SURREY PL CTR,TORONTO M5S 2C2,ON,CANADA

[4] UNIV TORONTO,DEPT OBSTET & GYNAECOL,TORONTO,ON,CANADA

来源：

BRAIN RESEARCH | 1994年 / 659卷 / 1-2期

关键词：

GENE EXPRESSION; OXIDATIVE STRESS; MOTONEURON; AMYOTROPHIC LATERAL SCLEROSIS; SUPEROXIDE DISMUTASE;

D O I：

10.1016/0006-8993(94)90892-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mutations of the Cu/Zn superoxide dismutase (SOD-1) gene were recently implicated in the pathogenesis of familial amyotrophic lateral sclerosis (ALS). We measured SOD-1 mRNA levels in motorneurons of the more common sporadic form of the disease and found a 42% increase in ALS motorneurons (P = 0.058) as compared with controls. These results suggest that oxidative stress may also play a role in the pathogenesis of sporadic ALS.

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页码：272 / 276

页数：5

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