METABOTROPIC GLUTAMATE-RECEPTOR AGONIST TRANS-AZETIDINE-2,4-DICARBOXYLIC ACID FACILITATES MAINTENANCE OF LTP IN THE DENTATE GYRUS IN-VIVO

被引：27

作者：

RIEDEL, G

MANAHANVAUGHAN, D

KOZIKOWSKI, AP

REYMANN, KG

机构：

[1] FED INST NEUROBIOL,DEPT NEUROPHYSIOL,D-39008 MAGDEBURG,GERMANY

[2] NEUROCHEM RES LAB,PRINCETON,NJ 08540

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 08期

关键词：

METABOTROPIC GLUTAMATE RECEPTORS (MGLURS); LONG-TERM POTENTIATION (LTP); TRANS-AZETIDINE-2,4-DICARBOXYLIC ACID (TADA);

D O I：

10.1016/0028-3908(95)00110-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the role of metabotropic glutamate receptors by studying the effect of intracerebroventricular infusion of the putative mGluR agonist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potentiation (LTP) in the dentate gyrus of freely moving rats. Weak tetanization caused a decremental potentiation which returned to baseline levels within 2 hr. Injections of tADA (20 mM/5 mu 1) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.

引用

页码：1107 / 1109

页数：3

共 11 条

[1] COACTIVATION OF METABOTROPIC GLUTAMATE AND N-METHYL-D-ASPARTATE RECEPTORS IS INVOLVED IN MECHANISMS OF LONG-TERM POTENTIATION MAINTENANCE IN RAT HIPPOCAMPAL CA1 NEURONS [J].