CONTROL OF DOUBLESEX ALTERNATIVE SPLICING BY TRANSFORMER AND TRANSFORMER-2 IN DROSOPHILA

被引：276

作者：

HOSHIJIMA, K ^{[1
]}

INOUE, K ^{[1
]}

HIGUCHI, I ^{[1
]}

SAKAMOTO, H ^{[1
]}

SHIMURA, Y ^{[1
]}

机构：

[1] KYOTO UNIV,FAC SCI,DEPT BIOPHYS,KYOTO 606,JAPAN

来源：

SCIENCE | 1991年 / 252卷 / 5007期

关键词：

D O I：

10.1126/science.1902987

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sex-specific alternative processing of doublesex (dsx) precursor messenger RNA (pre-mRNA) regulates somatic sexual differentiation in Drosophila melanogaster. Cotransfection analyses in which the dsx gene and the female-specific transformer (tra) and transformer-2 (tra-2) complementary DNAs were expressed in Drosophila Kc cells revealed that female-specific splicing of the dsx transcript was positively regulated by the products of the tra and tra-2 genes. Furthermore, analyses of mutant constructs of dsx showed that a portion of the female-specific exon sequence was required for regulation of dsx pre-messenger RNA splicing.

引用

页码：833 / 836

页数：4

共 23 条

[1] THE SEX-DETERMINING GENE TRA-2 OF DROSOPHILA ENCODES A PUTATIVE RNA-BINDING PROTEIN [J].