THE EFFICACY OF TREATMENT WITH ALBENDAZOLE

被引：10

作者：

HANJEET, K

MATHIAS, RG ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT HLTH CARE & EPIDEMIOL,VANCOUVER V6T 1Z3,BC,CANADA

[2] INST MED RES,DEPT PARASITOL,KUALA LUMPUR,MALAYSIA

来源：

ACTA TROPICA | 1991年 / 50卷 / 02期

关键词：

HELMINTHIASIS; SOIL-TRANSMITTED; ALBENDAZOLE; TRICHURIS; ASCARIS;

D O I：

10.1016/0001-706X(91)90003-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Albendazole, a benzimidazole derivative, was administered as a single dose of either 400 mg or 600 mg to two groups to ascertain the efficacy, tolerance and safety of the regimens. At a dose of 400 mg, a cure rate 35/36 (97%) against Ascaris was found. At 600 mg, the cure rate was 21/30 (70%), significantly lower than the 400 mg rate. Against Trichuris, albendazole at 400 mg had a cure rate of 21/48 (44%), at 600 mg there was a cure rate of 29/43 (67%). Mild side effects were noted in 7 individuals. Whether the moderate increase in efficacy against Trichuris and the loss of efficacy against Ascaris improves the cost:benefit ratio must be left to the prescriber of the drug,

引用

页码：111 / 114

页数：4

共 10 条

[1]

Dissanaike A. S., 1978, Drugs, V15, P11

[2]

Kan S. P., 1983, Asean Journal of Clinical Sciences, V4, P285

[3] EFFICACY OF SINGLE DOSES OF MEBENDAZOLE IN THE TREATMENT OF TRICHURIS-TRICHIURA INFECTION [J].