SERUM SELENIUM CONCENTRATION AND DISEASE PROGRESS IN PATIENTS WITH HIV-INFECTION

被引：69

作者：

CIRELLI, A ^{[1
]}

CIARDI, M ^{[1
]}

DESIMONE, C ^{[1
]}

SORICE, F ^{[1
]}

GIORDANO, R ^{[1
]}

CIARALLI, L ^{[1
]}

COSTANTINI, S ^{[1
]}

机构：

[1] IST SUPER SANITA,APPL TOXICOL LAB,I-00161 ROME,ITALY

来源：

CLINICAL BIOCHEMISTRY | 1991年 / 24卷 / 02期

关键词：

SELENIUM; HIV INFECTION;

D O I：

10.1016/0009-9120(91)90601-A

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The selenium concentration in the serum of 67 patients with HIV infection was measured to determine whether selenium deficiency occurred in the different stages of the disease. In the first stage of the study, patients were divided into four groups: symptom-free subjects, PGL (persistent generalized lymphadenopathy), ARC (AIDS related complex), and AIDS (acquired immunodeficiency syndrome). Selenium concentrations were normal in HIV antibody positive symptom-free subjects (1.18 +/- 0.27-mu-mol/L) and lower than normal in the other three groups (p < 0.001). There was a significant correlation (p < 0.001) between selenium levels and values of hemoglobin and erythrocyte sedimentation rate. Selenium deficiency was in no case associated with a lack of zinc in serum (also determined in all patients). In the second stage of the study, 12 patients were treated for a period of two months with low doses of selenium to assess whether such supplementation was able to restore their impaired immunological and hematological functions. The therapy increased serum selenium concentrations (from 0.77 +/- 0.23 to 1.44 +/- 0.41-mu-mol/L) and symptomatic improvements were noted. However, no changes were observed in the immunological and hematological parameters.

引用

页码：211 / 214

页数：4

共 26 条

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