STRATEGIES IN THE DESIGN OF SOLUTION-STABLE, WATER-SOLUBLE PRODRUGS .1. A PHYSICAL ORGANIC APPROACH TO PRO-MOIETY SELECTION FOR 21-ESTERS OF CORTICOSTEROIDS

被引：43

作者：

ANDERSON, BD ^{[1
]}

CONRADI, RA ^{[1
]}

KNUTH, KE ^{[1
]}

机构：

[1] UPJOHN CO,KALAMAZOO,MI 49001

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1985年 / 74卷 / 04期

关键词：

D O I：

10.1002/jps.2600740402

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：365 / 374

页数：10

共 43 条

[1] INFLUENCE OF PREMICELLAR AND MICELLAR ASSOCIATION ON THE REACTIVITY OF METHYLPREDNISOLONE 21-HEMIESTERS IN AQUEOUS-SOLUTION [J].

ANDERSON, BD ;

CONRADI, RA ;

JOHNSON, K .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (04) :448-454

[2] CARBOXYL GROUP CATALYSIS OF ACYL TRANSFER-REACTIONS IN CORTICOSTEROID 17-MONOESTERS AND 21-MONOESTERS [J].

ANDERSON, BD ;

CONRADI, RA ;

LAMBERT, WJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (05) :604-611

[3] INITIAL RATE STUDIES OF HYDROLYSIS AND ACYL MIGRATION IN METHYLPREDNISOLONE 21-HEMISUCCINATE AND 17-HEMISUCCINATE [J].

ANDERSON, BD ;

TAPHOUSE, V .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (02) :181-186

[4]

BARKE JT, 1980, J PHARM SCI, V69, P909

[5]

BERNARD SA, 1961, J AM CHEM SOC, V84, P2471

[6]

Capon B., 1976, NEIGHBORING GROUP PA, V1

[7]

CHARTON M, 1977, DESIGN BIOPHARMACEUT, P237

[8]

CHARTON M, 1977, DESIGN BIOPHARMACEUT, P236

[9]

CHARTON M, 1977, DESIGN BIOPHARMACEUT, P166

[10]

Dekker D, 1980, PHARM WEEKBLAD, V2, P1116

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