EXPRESSED GENES, ALU REPEATS AND POLYMORPHISMS IN COSMIDS SEQUENCED FROM CHROMOSOME-4P16.3

被引：47

作者：

MCCOMBIE, WR

MARTINGALLARDO, A

GOCAYNE, JD

FITZGERALD, M

DUBNICK, M

KELLEY, JM

CASTILLA, L

LIU, LI

WALLACE, S

TRAPP, S

TAGLE, D

WHALEY, WL

CHENG, S

GUSELLA, J

FRISCHAUF, AM

POUSTKA, A

LEHRACH, H

COLLINS, FS

KERLAVAGE, AR

FIELDS, C

VENTER, JC

机构：

[1] NINCDS,RECEPTOR BIOCHEM & MOLEC BIOL SECT,BETHESDA,MD 20892

[2] IMPERIAL CANC RES FUND,DEPT GENOME ANAL,LONDON WC2A 3PX,ENGLAND

[3] UNIV MICHIGAN,DEPT HUMAN GENET,ANN ARBOR,MI 48109

[4] UNIV MICHIGAN,DEPT INTERNAL MED,ANN ARBOR,MI 48109

[5] UNIV MICHIGAN,HOWARD HUGHES MED INST,ANN ARBOR,MI 48109

[6] HARVARD UNIV,DEPT GENET,BOSTON,MA 02129

[7] DEUTSCH KREBSFORSCHUNGSZENTRUM,W-6900 HEIDELBERG,GERMANY

[8] MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET LAB,BOSTON,MA 02114

来源：

NATURE GENETICS | 1992年 / 1卷 / 05期

关键词：

D O I：

10.1038/ng0892-348

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The sequences of three cosmids (90 kilobases) from the Huntington's disease region in chromosome 4p16.3 have been determined. A 30,837 base overlap of DNA sequenced from two individuals was found to contain 72 DNA sequence polymorphisms, an average of 2.3 polymorphisms per kilobase (kb). The assembled 58 kb contig contains 62 Alu repeats, and eleven predicted exons representing at least three expressed genes that encode previously unidentified proteins. Each of these genes is associated with a CpG island. The structure of one of the new genes, hda1-1, has been determined by characterizing cDNAs from a placental library. This gene is expressed in a variety of tissues and may encode a novel housekeeping gene.

引用

页码：348 / 353

页数：6

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