ROLE OF TISSUE FACTOR IN DISSEMINATED INTRAVASCULAR COAGULATION

被引：60

作者：

ASAKURA, H

KAMIKUBO, Y

GOTO, A

SHIRATORI, Y

YAMAZAKI, M

JOKAJI, H

SAITO, M

UOTANI, C

KUMABASHIRI, I

MORISHITA, E

AOSHIMA, K

NAKAMURA, S

MATSUDA, T

机构：

[1] CHEMO SERO THERAPEUT RES INST,DIV BLOOD PROD,KUMAMOTO,JAPAN

[2] GIFU UNIV,SCH MED,GIFU 500,JAPAN

[3] KYOTO UNIV,PRIMATE RES INST,DEPT BIOCHEM,INUYAMA,AICHI 484,JAPAN

来源：

THROMBOSIS RESEARCH | 1995年 / 80卷 / 03期

关键词：

TISSUE FACTOR; DISSEMINATED INTRAVASCULAR COAGULATION; MULTIPLE ORGAN FAILURE;

D O I：

10.1016/0049-3848(95)00170-V

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined plasma antigen levels of tissue factor (TF) in 95 cases of disseminated intravascular coagulation (DIC), to investigate the role of TF in DIC. A significant elevation of plasma antigen levels of TF was observed in cases of DIC associated with cancer. However, no such significant elevation was observed in cases of DIC associated with acute promyelocytic leukemia (APL), acute leukemia except APL, blastic crisis of chronic myelogenous leukemia, non-Hodgkin lymphoma (NHL), sepsis or fulminant hepatitis. No significant elevation of TF was observed in patients without DIC, except 4 cases of cancer who developed DIC thereafter. Plasma antigen levels of TF were higher in bath cases of DIC with renal failure and chronic renal failure without DIC than its levels in those without renal failure. Therefore,plasma antigen levels of TF in DIC patients with renal failure were considered to be carefully estimated. The levels of TF were decreased with the clinical improvement in some cases of DIC but were further increased or remained at high levels in patients who showed no improvement of DIC. Thus, plasma antigen levels of TF is an important marker to predict the development and/or prognosis of DIC, especially in patients with cancer.

引用

页码：217 / 224

页数：8

共 27 条

[21] ACTIVATION OF FACTOR-VII BOUND TO TISSUE FACTOR - A KEY EARLY STEP IN THE TISSUE FACTOR PATHWAY OF BLOOD-COAGULATION [J].