1ST PASS HYDROXYLATION OF NORTRIPTYLINE - CONCENTRATIONS OF PARENT DRUG AND MAJOR METABOLITES IN PLASMA

被引：52

作者：

ALVAN, G

BORGA, O

LIND, M

PALMER, L

SIWERS, B

机构：

[1] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT CLIN PHARMACOL,S-14186 HUDDINGE,SWEDEN

[2] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT PSYCHIAT,S-14186 HUDDINGE,SWEDEN

[3] KAROLINSKA INST,SWEDISH MED RES COUNCIL,DEPT TOXICOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1977年 / 11卷 / 03期

关键词：

D O I：

10.1007/BF00606414

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：219 / 224

页数：6

共 18 条

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[4]

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[6]

BORGA O, 1973, 5TH P INT C PHARM SA, V3, P56

[7] COMPARISON OF OBSERVED AND PREDICTED BIOAVAILABILITY OF NORTRIPTYLINE IN HUMANS FOLLOWING ORAL-ADMINISTRATION [J].

GIBALDI, M .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (06) :1036-1037

[8] INFLUENCE OF FIRST-PASS EFFECT ON AVAILABILITY OF DRUGS ON ORAL ADMINISTRATION [J].

GIBALDI, M ;

BOYES, RN ;

FELDMAN, S .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1971, 60 (09) :1338-&

[9]

GRAM LF, 1975, CLIN PHARMACOL THER, V18, P305

[10]

GRAM LF, 1975, CLIN PHARMACOL THER, V17, P555

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