AGING AND ALZHEIMERS-DISEASE - PROTEASE INHIBITORS IN CEREBROSPINAL-FLUID

被引:19
作者
DELAMARCHE, C [1 ]
BERGER, F [1 ]
GALLARD, L [1 ]
POUPLARDBARTHELAIX, A [1 ]
机构
[1] CHR ANGERS,INSERM,U298,F-49033 ANGERS,FRANCE
关键词
ALZHEIMERS DISEASE; AGING; PROTEASE INHIBITORS; CEREBROSPINAL FLUID;
D O I
10.1016/0197-4580(91)90042-I
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Recent advances suggested that proteases and their inhibitors could be implicated in the genesis and/or maturation of insoluble deposits associated with Alzheimer's disease (AD). This study was designed to measure the level of alpha-1-antichymotrypsin (ACT) and alpha-1-antitrypsin (AT) in cerebrospinal fluid (CSF) of patients with AD and nondemented humans at various ages. Our analysis failed to demonstrate a significant relationship between inhibitor content and disease. However, a positive correlation was observed between age and the ACT level for the normal control group. Such observation suggests a specific association of ACT with the mechanisms of brain aging.
引用
收藏
页码:71 / 74
页数:4
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