AGING AND ALZHEIMERS-DISEASE - PROTEASE INHIBITORS IN CEREBROSPINAL-FLUID

被引：19

作者：

DELAMARCHE, C ^{[1
]}

BERGER, F ^{[1
]}

GALLARD, L ^{[1
]}

POUPLARDBARTHELAIX, A ^{[1
]}

机构：

[1] CHR ANGERS,INSERM,U298,F-49033 ANGERS,FRANCE

来源：

NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 01期

关键词：

ALZHEIMERS DISEASE; AGING; PROTEASE INHIBITORS; CEREBROSPINAL FLUID;

D O I：

10.1016/0197-4580(91)90042-I

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Recent advances suggested that proteases and their inhibitors could be implicated in the genesis and/or maturation of insoluble deposits associated with Alzheimer's disease (AD). This study was designed to measure the level of alpha-1-antichymotrypsin (ACT) and alpha-1-antitrypsin (AT) in cerebrospinal fluid (CSF) of patients with AD and nondemented humans at various ages. Our analysis failed to demonstrate a significant relationship between inhibitor content and disease. However, a positive correlation was observed between age and the ACT level for the normal control group. Such observation suggests a specific association of ACT with the mechanisms of brain aging.

引用

页码：71 / 74

页数：4

共 28 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].