THE B-CELL ANTIGEN CD22 MEDIATES MONOCYTE AND ERYTHROCYTE ADHESION

被引：187

作者：

STAMENKOVIC, I

SEED, B

机构：

[1] HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115

[2] MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114

来源：

NATURE | 1990年 / 345卷 / 6270期

关键词：

D O I：

10.1038/345074a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

INTERACTION with antigen-presenting accessory cells is thought to be an important step in B-cell activation1-5, and the B-cell receptor CD22, which is coordinately expressed with surface immunoglobulin, has been proposed to participate in the antigen response6. Here we show that CD22 has a structure closely related to myelin-associated glycoprotein (MAG, a neuronal adhesion protein), and mediates monocyte and erythrocyte adhesion. Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen recognition by promoting antigen-nonspecific contacts with accessory cells. © 1990 Nature Publishing Group.

引用

页码：74 / 77

页数：4

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