TUNNELING IN LIGAND-BINDING TO HEME PROTEINS

被引：116

作者：

ALBERDING, N

AUSTIN, RH

BEESON, KW

CHAN, SS

EISENSTEIN, L

FRAUENFELDER, H

NORDLUND, TM

机构：

[1] UNIV ILLINOIS, DEPT PHYS, URBANA, IL 61801 USA

[2] UNIV ILLINOIS, DEPT BIOPHYS, URBANA, IL 61801 USA

来源：

SCIENCE | 1976年 / 192卷 / 4243期

关键词：

D O I：

10.1126/science.1273579

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rebinding of CO to the beta chain of Hb after photodissociation by a laser flash is intramolecular below about 200.degree. K. Above 25.degree. K, rebinding occurs via classical over-the-barrier motion; below, quantum-mechanical tunneling dominates. Both are described by an energy spectrum peaked at Epeak = 4.0 kjoules/mol. The barrier width d(E), determined from the energy dependence of the tunneling rate, depends on barrier height, d(E) .apprxeq. 0.05 nanometer .times. (E/Epeak)1.5.

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页码：1002 / 1004

页数：3

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