TH1 AND TH2 SUBSETS - PARADIGMS LOST

被引：449

作者：

KELSO, A

机构：

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0167-5699(95)80004-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The T helper 1 (Th1)/Th2 model has provided a valuable framework to investigate and explain many immune reactions and now pervades current thinking on the regulatory role of T cells. However, individual T cells and clones display remarkable diversity in their cytokine profiles, collectively forming a continuous spectrum in which Th1 and Th2 cells may be only two of-the possible extreme phenotypes. For these reasons, Anne Kelso argues that cytokine-producing T cells cannot be classified into discrete subsets.

引用

收藏

页码：374 / 379

页数：6

相关论文

共 41 条

[1] FLOW CYTOMETRIC DETERMINATION OF CYTOKINES IN ACTIVATED MURINE T-HELPER LYMPHOCYTES - EXPRESSION OF INTERLEUKIN-10 IN INTERFERON-GAMMA AND IN INTERLEUKIN-4-EXPRESSING CELLS [J].

ASSENMACHER, M ;

SCHMITZ, J ;

RADBRUCH, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (05) :1097-1101

[2] NOVEL FEATURES OF THE RESPIRATORY-TRACT T-CELL RESPONSE TO INFLUENZA-VIRUS INFECTION - LUNG T-CELLS INCREASE EXPRESSION OF GAMMA-INTERFERON MESSENGER-RNA IN-VIVO AND MAINTAIN HIGH-LEVELS OF MESSENGER-RNA EXPRESSION FOR INTERLEUKIN-5 (IL-5) AND IL-10 [J].

BAUMGARTH, N ;

BROWN, L ;

JACKSON, D ;

KELSO, A .

JOURNAL OF VIROLOGY, 1994, 68 (11) :7575-7581

[3] HETEROGENEITY OF SINGLE-CELL CYTOKINE GENE-EXPRESSION IN CLONAL T-CELL POPULATIONS [J].

BUCY, RP ;

PANOSKALTSISMORTARI, A ;

HUANG, GQ ;

LI, JM ;

KARR, L ;

ROSS, M ;

RUSSELL, JH ;

MURPHY, KM ;

WEAVER, CT .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1251-1262

[4] DIFFERENTIAL ACTIVATION OF CYTOKINE GENES IN NORMAL CD4-BEARING T-CELLS IS STIMULUS DEPENDENT [J].

CARDING, SR ;

WEST, J ;

WOODS, A ;

BOTTOMLY, K .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (02) :231-238

[5] ROLE OF CYTOKINES IN THE DIFFERENTIATION OF CD4+ T-CELL SUBSETS INVIVO [J].

COFFMAN, RL ;

VARKILA, K ;

SCOTT, P ;

CHATELAIN, R .

IMMUNOLOGICAL REVIEWS, 1991, 123 :189-207

[6]

FIRESTEIN GS, 1989, J IMMUNOL, V143, P518

[7] REGULATION OF T-CELL ACTIVATION - DIFFERENCES AMONG T-CELL SUBSETS [J].

GAJEWSKI, TF ;

SCHELL, SR ;

NAU, G ;

FITCH, FW .

IMMUNOLOGICAL REVIEWS, 1989, 111 :79-110

[8] RECOMBINANT INTERLEUKIN-12 CURES MICE INFECTED WITH LEISHMANIA-MAJOR [J].

HEINZEL, FP ;

SCHOENHAUT, DS ;

RERKO, RM ;

ROSSER, LE ;

GATELY, MK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (05) :1505-1509

[9] RECIPROCAL EXPRESSION OF INTERFERON-GAMMA OR INTERLEUKIN-4 DURING THE RESOLUTION OR PROGRESSION OF MURINE LEISHMANIASIS - EVIDENCE FOR EXPANSION OF DISTINCT HELPER T-CELL SUBSETS [J].

HEINZEL, FP ;

SADICK, MD ;

HOLADAY, BJ ;

COFFMAN, RL ;

LOCKSLEY, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) :59-72

[10] DEVELOPMENT OF TH1 CD4+ T-CELLS THROUGH IL-12 PRODUCED BY LISTERIA-INDUCED MACROPHAGES [J].

HSIEH, CS ;

MACATONIA, SE ;

TRIPP, CS ;

WOLF, SF ;

OGARRA, A ;

MURPHY, KM .

SCIENCE, 1993, 260 (5107) :547-549

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