5-AZACYTIDINE SELECTIVELY INCREASES GAMMA-GLOBIN SYNTHESIS IN A PATIENT WITH BETA+-THALASSEMIA

被引:498
作者
LEY, TJ
DESIMONE, J
ANAGNOU, NP
KELLER, GH
HUMPHRIES, RK
TURNER, PH
YOUNG, NS
HELLER, P
NIENHUIS, AW
机构
[1] UNIV ILLINOIS,COLL MED,CHICAGO,IL 60680
[2] W SIDE VET ADM HOSP,CHICAGO,IL
关键词
D O I
10.1056/NEJM198212093072401
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1469 / 1475
页数:7
相关论文
共 34 条
[1]  
ALTER BP, 1976, BLOOD, V48, P843
[2]  
ALTER BP, 1979, BIOCH BIOPHYS RES CO, V94, P843
[3]  
BENZ EJ, 1979, J BIOL CHEM, V254, P6880
[4]   5-AZACYTIDINE-INDUCED REACTIVATION OF A HERPES-SIMPLEX THYMIDINE KINASE GENE [J].
CLOUGH, DW ;
KUNKEL, LM ;
DAVIDSON, RL .
SCIENCE, 1982, 216 (4541) :70-73
[5]   DNA METHYLATION CONTROLS THE INDUCIBILITY OF THE MOUSE METALLOTHIONEIN-I GENE IN LYMPHOID-CELLS [J].
COMPERE, SJ ;
PALMITER, RD .
CELL, 1981, 25 (01) :233-240
[6]   PHENOTYPIC CONVERSION OF CULTURED MOUSE EMBRYO CELLS BY AZA PYRIMIDINE NUCLEOSIDES [J].
CONSTANTINIDES, PG ;
TAYLOR, SM ;
JONES, PA .
DEVELOPMENTAL BIOLOGY, 1978, 66 (01) :57-71
[7]  
CREUSOT F, 1982, J BIOL CHEM, V257, P2041
[8]  
DESIMONE J, 1980, J CLIN INVEST, V65, P224, DOI 10.1172/JCI109654
[9]   5-AZACYTIDINE STIMULATES FETAL HEMOGLOBIN-SYNTHESIS IN ANEMIC BABOONS [J].
DESIMONE, J ;
HELLER, P ;
HALL, L ;
ZWIERS, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (14) :4428-4431
[10]   GENETIC-RELATIONSHIP BETWEEN FETAL HB LEVELS IN NORMAL AND ERYTHROPOIETICALLY STRESSED BABOONS [J].
DESIMONE, J ;
HELLER, P ;
BIEL, M ;
ZWIERS, D .
BRITISH JOURNAL OF HAEMATOLOGY, 1981, 49 (02) :175-183