SPECIFICITY AND MECHANISM OF ACTION OF META-TYROSINE IN ANTAGONIZING CENTRAL EFFECTS OF RESERPINE IN RATS

被引：7

作者：

STOOF, JC ^{[1
]}

SCHIPPER, J ^{[1
]}

MULDER, AH ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM, FAC MED, DEPT PHARMACOL, AMSTERDAM, NETHERLANDS

来源：

NEUROPHARMACOLOGY | 1976年 / 15卷 / 07期

关键词：

D O I：

10.1016/0028-3908(76)90112-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The interaction between m-tyrosine and reserpine was investigated. m-Tyrosine, when given in repeated doses shortly before and after the injection of reserpine, caused a partial but significant protection against the dopamine-depleting action of reserpine in the brain. Pretreatment with m-tyrosine also partially protected against the marked reductions in synaptosomal [3H]dopamine uptake and in release of [3H]dopamine from striatal slices prepared from rats pretreated with reserpine. However, 5-hydroxytryptophan and dopa also appeared to have a protective action against reserpine, comparable with that of m-tyrosine. The interaction between m-tyrosine and reserpine, resulting in a protection of the dopamine stores against depletion, is not a specific effect.

引用

页码：379 / 382

页数：4

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