PERIPHERAL SELECTION OF THE T-CELL REPERTOIRE

被引：638

作者：

ROCHA, B ^{[1
]}

VONBOEHMER, H ^{[1
]}

机构：

[1] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

来源：

SCIENCE | 1991年 / 251卷 / 4998期

关键词：

D O I：

10.1126/science.1900951

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T lymphocytes undergo selection events not only in the thymus, but also after they leave the thymus and reside in the periphery. Peripheral selection was found to be dependent on T cell receptor (TCR)-ligand interactions but to differ from thymic selection with regard to specificity and mechanism. Unlike thymic selection, peripheral selection required binding of antigen to the TCR, and it induced expansion of T cell clones. Tolerance to self antigens that are restricted to the periphery occurred through the elimination of self-reactive T cells and by the clonal anergy, which was associated with down-regulation of the alpha-beta-TCR and CD8.

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页码：1225 / 1228

页数：4

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