THE EFFECT OF A DEVELOPING NEO-INTIMA ON SEROTONERGIC AND ADRENERGIC CONTRACTIONS

被引：37

作者：

DEMEYER, GRY ^{[1
]}

BULT, H ^{[1
]}

MARTIN, JF ^{[1
]}

VANHOYDONCK, AE ^{[1
]}

HERMAN, AG ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 187卷 / 03期

关键词：

(Rabbit); 5-HT; (5-hydroxytryptamine; serotonin); Atherosclerosis; Hyperreactivity; Neo-intima;

D O I：

10.1016/0014-2999(90)90380-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study we used a new model, in which the positioning of a non-occlusive collar around the rabbit carotid artery results, within 7 days, in the generation of a neo-intima, a precursor lesion of atherosclerosis. We investigated the effects of this intimal proliferation on the responsiveness to serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NOR) after 1, 2 and 7 days. Already after 1 day the collar-treated arteries were more sensitvie to 5-HT, but not to NOR. This sensitivity persisted over a period of 7 days. However, the development of a neo-intima diminished the maximum contractile force to NOR after 2 and 7 days, but not to 5-HT. These results demonstrate that there is a relatively selective increase in sensitivity to 5-HT during neo-intima formation, even without hypercholesterolaemia. © 1990.

引用

页码：519 / 524

页数：6

共 25 条

[1] 5-HT RECEPTORS IN THE CORONARY CIRCULATION [J].