STUDIES ON METABOLISM OF TRAZODONE .4. INTESTINAL-ABSORPTION IN RATS AND RABBITS

被引：3

作者：

YAMATO, C ^{[1
]}

TAKAHASHI, T ^{[1
]}

FUJITA, T ^{[1
]}

机构：

[1] EISAI CO LTD, DEPT DRUG METAB,DIV RES & DEV, EXPTL THERAPEUTICS RES SECT,BUNKYOKU, TOKYO, JAPAN

来源：

XENOBIOTICA | 1976年 / 6卷 / 09期

关键词：

D O I：

10.3109/00498257609151664

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The absorption rates are the same in rats and rabbits when [14C]trazodone hydrochloride, a new psychotropic drug, is injected into the duodenum of animals with pyloric vein cannulation. The absorption of trazodone from the duodenum of rats is rapid in comparison with that of imipramine. The residual food content of the rabbit stomach after fasting delays the overall rate of trazodone absorption by markedly decreasing transit rate from the stomach to the small intestine.

引用

页码：521 / 529

页数：9

共 9 条

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XENOBIOTICA, 1976, 6 (05) :295-306

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