NEW INSIGHTS INTO T-CELL ANTIGEN RECEPTOR STRUCTURE AND SIGNAL TRANSDUCTION

被引:44
作者
CHAN, AC [1 ]
IRVING, BA [1 ]
WEISS, A [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,BOX 0724,3RD & PARNASSUS AVE,SAN FRANCISCO,CA 94143
关键词
D O I
10.1016/0952-7915(92)90072-M
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent studies have provided insights into how the complex structure of the T-cell antigen receptor relates to its signal transduction function. Both the CD3 and zeta-subunits contain functioning signaling modules that regulate the activation of tyrosine kinases and phosphorylation of cellular substrates.
引用
收藏
页码:246 / 251
页数:6
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