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INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) EXPRESSION IN THE ISLETS OF THE NONOBESE DIABETIC AND LOW-DOSE STREPTOZOCIN-TREATED MOUSE

被引：15
作者：
LINN, T
STRATE, C
FEDERLIN, K
PAPACCIO, G
机构：
[1] UNIV GIESSEN,SCH MED,MED CLIN 3,D-35385 GIESSEN,GERMANY
[2] UNIV NAPLES 2,SCH MED,INST ANAT,I-80138 NAPLES,ITALY
来源：
HISTOCHEMISTRY | 1994年 / 102卷 / 04期
关键词：
D O I：
10.1007/BF00269169
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The expression of intercellular adhesion molecule-1 (ICAM-1) was studied in 8-week-old non-obese diabetic (NOD) mice and low-dose streptozocin-treated (LDS) mice. ICAM-1 expression in NOD mice was observed at the islet periphery, corresponding to the peri-islet venular network, within the islet and on scattered elements along septa of the exocrine portion of the pancreas. Image analysis demonstrated that LDS-treated animals had less ICAM-1 immunoreactivity within and around the islets compared to NOD mice. At the ultrastructural level the peri-islet vessels were found to be filled with mononuclear elements. Moreover, endothelial cells showed signs of activation, and margination of monocytes and polymorphonuclear leukocytes was observed.
引用
收藏
页码：317 / 321
页数：5
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