QUESTIONS ABOUT INHALED BETA-2-ADRENOCEPTOR AGONISTS IN ASTHMA

被引:67
作者
BARNES, PJ
CHUNG, KF
机构
[1] Department of Thoracic Medicine, National Heart and Lung Institute, London, SW3 6LY, Dovehouse Street
[2] in the Department of Thoracic Medicine, National Heart and Lung Institute, London, SW3 6LY, Dovehouse Street
关键词
D O I
10.1016/0165-6147(92)90011-T
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The safety of the most widely prescribed antiasthma drugs, beta(2)-adrenoceptor agonists, has recently been questioned. Issues such as their suitability for long-term and regular prophylactic use are addressed in this Comment article by Peter Barnes and Fan Chung, who examine the possibility that the beta(2)-agonists themselves contribute to worsening symptoms in asthma patients, thus setting up a vicious circle with greater use of the drugs. They conclude that it would be prudent to restrict the use of beta(2)-agonists in asthma to on-demand immediate symptom control.
引用
收藏
页码:20 / 23
页数:4
相关论文
共 42 条
[1]  
AGE CP, 1991, LANCET, V337, P717
[2]  
ANDERSON SD, 1976, AM REV RESPIR DIS, V114, P493
[3]  
BARNES PJ, 1989, NEW ENGL J MED, V321, P1517
[4]   NEW CONCEPTS IN THE PATHOGENESIS OF BRONCHIAL HYPERRESPONSIVENESS AND ASTHMA [J].
BARNES, PJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1989, 83 (06) :1013-1026
[5]   SOME INTERNATIONAL COMPARISONS OF MORTALITY AMENABLE TO MEDICAL INTERVENTION [J].
CHARLTON, JRH ;
VELEZ, R .
BMJ-BRITISH MEDICAL JOURNAL, 1986, 292 (6516) :295-301
[6]   INHIBITION OF IGE-DEPENDENT HISTAMINE-RELEASE FROM HUMAN DISPERSED LUNG MAST-CELLS BY ANTIALLERGIC DRUGS AND SALBUTAMOL [J].
CHURCH, MK ;
HIROI, J .
BRITISH JOURNAL OF PHARMACOLOGY, 1987, 90 (02) :421-429
[8]   CARDIOVASCULAR AND HYPOKALEMIC EFFECTS OF INHALED SALBUTAMOL, FENOTEROL, AND ISOPRENALINE [J].
CRANE, J ;
BURGESS, C ;
BEASLEY, R .
THORAX, 1989, 44 (02) :136-140
[9]  
CRANE J, 1989, LANCET, V1, P917
[10]   MUCOSAL INFLAMMATION IN ASTHMA [J].
DJUKANOVIC, R ;
ROCHE, WR ;
WILSON, JW ;
BEASLEY, CRW ;
TWENTYMAN, OP ;
HOWARTH, PH ;
HOLGATE, ST .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (02) :434-457