SPONTANEOUS RECURRENT SEIZURES IN RATS - AN EXPERIMENTAL-MODEL OF PARTIAL EPILEPSY

被引:210
作者
LEITE, JP
BORTOLOTTO, ZA
CAVALHEIRO, EA
机构
[1] Laboratório de Neurologia Experimental, Escola Paulista de Medicina, São Paulo, SP
关键词
Brain damage; Kindling; Neurotoxicity; Pilocarpine; Spontaneous seizures;
D O I
10.1016/S0149-7634(05)80076-4
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Seizures induced by pilocarpine (PILO) have proven to be a useful procedure for investigating the basic mechanisms essential for generation, spread and motor expression of seizures in rodents. Here we report the long-term effects of PILO in rats. Following PILO (380 mg/kg, IP), 3 distinct phases were observed: 1) an acute period which lasted 1-2 days which corresponds to the pattern of repetitive seizures and status epilepticus; 2) a silent period (4-44 days) characterized by a progressive return to normal EEG and behavior; and 3) a period of recurrent seizures which started 5-45 days after PILO and lasted up to 120 days. These seizures lasted up to 50-60 sec, recurred 2-3 times per week and were more frequent during the light period of the light-dark cycle. These serial events offer a new method to induce spontaneous recurrent seizures in rats. © 1990 Pergamon Press plc.
引用
收藏
页码:511 / 517
页数:7
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