IMIPRAMINE DEMETHYLATION AND HYDROXYLATION - IMPACT OF THE SPARTEINE OXIDATION PHENOTYPE

被引:109
作者
BROSEN, K
OTTON, SV
GRAM, LF
机构
关键词
D O I
10.1038/clpt.1986.221
中图分类号
R9 [药学];
学科分类号
1007 ;
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页码:543 / 549
页数:7
相关论文
共 28 条
[1]   THE DEBRISOQUINE HYDROXYLATION TEST PREDICTS STEADY-STATE PLASMA-LEVELS OF DESIPRAMINE [J].
BERTILSSON, L ;
ABERGWISTEDT, A .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 15 (03) :388-390
[2]  
BROSEN K, 1985, ACTA PHARMACOL TOX, V57, P357
[3]   SPARTEINE OXIDATION POLYMORPHISM - A FAMILY STUDY [J].
BROSEN, K ;
OTTON, SV ;
GRAM, LF .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 21 (06) :661-667
[4]   STEADY-STATE LEVELS OF IMIPRAMINE AND ITS METABOLITES - SIGNIFICANCE OF DOSE-DEPENDENT KINETICS [J].
BROSEN, K ;
GRAM, LF ;
KLYSNER, R ;
BECH, P .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 30 (01) :43-49
[5]  
BROSEN K, 1986, EUR J CLIN PHARM, V30
[6]  
BROSEN K, 1985, UNPUB
[7]   CHARACTERIZATION OF A HUMAN-LIVER CYTOCHROME-P-450 INVOLVED IN THE OXIDATION OF DEBRISOQUINE AND OTHER DRUGS BY USING ANTIBODIES RAISED TO THE ANALOGOUS RAT ENZYME [J].
DISTLERATH, LM ;
GUENGERICH, FP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23) :7348-7352
[8]   INTER-ETHNIC DIFFERENCE IN SPARTEINE OXIDATION AMONG GHANAIANS AND GERMANS [J].
EICHELBAUM, M ;
WOOLHOUSE, NM .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 28 (01) :79-83
[9]   THE GENETIC-CONTROL OF SPARTEINE AND DEBRISOQUINE METABOLISM IN MAN WITH NEW METHODS OF ANALYZING BIMODAL DISTRIBUTIONS [J].
EVANS, DAP ;
HARMER, D ;
DOWNHAM, DY ;
WHIBLEY, EJ ;
IDLE, JR ;
RITCHIE, J ;
SMITH, RL .
JOURNAL OF MEDICAL GENETICS, 1983, 20 (05) :321-329
[10]  
GLASSMAN AH, 1977, ARCH GEN PSYCHIAT, V34, P197