ALTERED INFLAMMATORY RESPONSES IN LEUKOTRIENE-DEFICIENT MICE

被引：175

作者：

GOULET, JL

SNOUWAERT, JN

LATOUR, AM

COFFMAN, TM

KOLLER, BH

机构：

[1] UNIV N CAROLINA,CURRICULUM GENET & MOLEC BIOL,CHAPEL HILL,NC 27599

[2] UNIV N CAROLINA,DEPT MED,CHAPEL HILL,NC 27599

[3] DUKE UNIV,DEPT MED,DURHAM,NC 27710

[4] DURHAM VET AFFAIRS MED CTR,DURHAM,NC 27710

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 26期

关键词：

5-LIPOXYGENASE; PROSTAGLANDINS; EICOSANOID; INDOMETHACIN; GENE TARGETING;

D O I：

10.1073/pnas.91.26.12852

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leukotrienes have been implicated in the regulation of immune responses, including inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene. These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor. The intensity of an acute inflammatory response induced by arachidonic acid was similar in 5LO(-/-) mice and controls. However, the response in 5LO(-/-) mice, but not in controls, could be virtually eliminated by a cyclooxygenase inhibitor. These data suggest that inflammatory responses are modulated by arachidonic acid metabolites through a variety of interconnected mechanisms. This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention.

引用

页码：12852 / 12856

页数：5

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