PULSED H/D-EXCHANGE STUDIES OF FOLDING INTERMEDIATES

被引：258

作者：

BALDWIN, RL ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,STANFORD,CA 94305

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0959-440X(93)90206-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pulsed peptide H/D exchange has been used recently to study intermediates on the folding pathways of nine small proteins, in eight laboratories. Patterns of folding behavior are beginning to emerge and some results are quite unexpected- The data are compared with predictions of a molten-globule model of protein folding.

引用

页码：84 / 91

页数：8

共 43 条

[1]

BALDWIN R L, 1991, Current Biology, V1, P218, DOI 10.1016/0960-9822(91)90061-Z

[2]

BALDWIN RL, 1991, CIBA F SYMP, V161, P190

[3]

BALDWIN RL, 1991, CHEMTRACTS BIOCH MOL, V2, P379

[4] EARLY HYDROGEN-BONDING EVENTS IN THE FOLDING REACTION OF UBIQUITIN [J].